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DCD – Innovative Tissue Engineering

Double Component Deposition (DCD)

Neoolife’s breakthrough DCD technology engineers biomimetic polymeric scaffolds that mimic the structure and function of human heart valves. These human-like-tissue scaffolds promote tissue restoration, offering resistance to calcification and thrombosis, and enable long-lasting valve performance. This innovation supports the manufacture of non-resorbable (permanent) and resorbable heart valves for a wide range of patients and valve types.

 

Using DCD innovative tissue engineering technology, Neoolife will:

 

  • Manufacture polymeric tissue-engineered Biomimetic Heart Valves for percutaneous and surgical implantation (aortic, mitral, pulmonary, and tricuspid).
  • Manufacture its proprietary tissue-engineered Biomimetic Percutaneous Tricuspid Heart Valve OneValveTric.
  • Manufacture polymeric tissue-engineered Biomimetic Patches to repair adult and pediatric heart valves and intracardiac defects.

Key Benefits

Non-Animal Derived

Intensive animal farming to support the medical industry is a polluting reservoir for pathogens causing lethal diseases in humans. Our animal-free technology eliminates transmission risks while maintaining supplies security.¹

Biomimicry

Neoolife’ s unique polymeric scaffolds mimic the natural structure, shape, size, and function of human heart valves. This biomimicry promotes endogenous tissue regeneration to achieve native living tissue remodeling.

Enhanced clinical performance

Immediately after implantation, Neoolife valves have a function equivalent to native heart valves. Moreover, the endogenous living tissue that populates the scaffold is non-thrombogenic, resistant to calcification, and durable.

Improved efficiency and customization

Neoolife products rely upon a more efficient, scalable, and less costly manufacturing process. Our products are based on consistent and reproducible quality, including robotic technology for a high level of precision and customization.

Unmet Clinical Need

The most commonly used prosthetic heart valves today, made from metal or animal tissue, come with serious limitations. These include reduced long-term durability and the requirement for lifelong blood-thinning medication, which increases the risk of complications such as bleeding, thrombosis, and valve failure, often leading to repeat surgeries. These issues severely impact patients’ quality of life, as well as their morbidity and mortality rates. Despite these drawbacks, there has been little advancement in valve materials over recent decades. Clinicians are now calling for more durable solutions.

Neoolife addresses these needs with its non-resorbable (permanent) and resorbable biomimetic polymeric tissue, which mimics the structure and properties of human tissue. Neoolife’s innovative and unique biomimetic polymeric tissue promotes the heart’s self-healing capabilities. We are committed to providing patients in need of heart valve replacement or repair with our breakthrough tissue technology, which offers extended long-term durability, eliminates the need for lifelong anticoagulation, and resists calcification and degeneration.

Caution: Neoolife products are in the R&D development and pre-clinical phase. They are NOT approved or cleared by the FDA or any other regulatory body in any region of the world.